Different substrate supply mechanisms to mitochondria from astrocytes and neurons support astrocyte–neuron lactate shuttle hypothesis
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منابع مشابه
Saturation of the lactate clearance mechanisms different from the "lactate shuttle" determines the anaerobic threshold: prediction from the bioenergetic model.
It is demonstrated, that the bioenergetic model combined with the mathematical constraints determined by the experimental knowledge of the aerobic metabolism and the Lohmann reaction dictates the exact lactate (La)-time relationship during exercise. The theory predicts that La is necessarily produced (above the resting baseline), even during extremely low work loads, where the metabolism was us...
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preference in human primary visual cortex (V1). Each line corresponds to a different voxel (a 2 2 2 mm cube of cortex) in V1; signals from each voxel were measured using functional magnetic resonance imaging. Orientation preference was measured by showing human observers stimuli like the oriented grating shown in the background. The location of each line represents the location in the visual fi...
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Lactate, the conjugate base of lactic acid occurring in aqueous biological fluids, has been derided as a "dead-end" waste product of anaerobic metabolism. Catalyzed by the near-equilibrium enzyme lactate dehydrogenase (LDH), the reduction of pyruvate to lactate is thought to serve to regenerate the NAD(+) necessary for continued glycolytic flux. Reaction kinetics for LDH imply that lactate oxid...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2012
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2012.06.210